fasn (Cell Signaling Technology Inc)
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Cell Signaling Technology Inc
fasn
Fasn, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 841 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/fasn/Fatty+Acid+Synthase+Rabbit+mAb/pm42882471-83-41-42
Average 96 stars, based on 841 article reviews
Fasn, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 96/100, based on 841 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/fasn/Fatty+Acid+Synthase+Rabbit+mAb/pm42882471-83-41-42
Average 96 stars, based on 841 article reviews
fasn - by Bioz Stars,
2026-10
96/100 stars
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SDS Page:Article Title: Impaired hepatic BMAL1-FGF21 signaling drives adverse metabolic outcomes of ketogenic diet. Article Snippet: Aims The ketogenic diet (KD) has gained popularity for its metabolic benefits; however, its effects vary markedly across physiological and pathological conditions.. This study aimed to determine the mechanisms underlying differential metabolic responses to KD.. Materials and Methods Db/db, liver-specific fibroblast growth factor 21 (FGF21) knockdown mice, and liverspecific brain and muscle aryl hydrocarbon receptor nuclear translocator-like 1 (BMAL1) knockout mice were treated with isocaloric KD for 8 weeks. Article Title: FASN-mediated metabolic reprogramming drives CD4 + T cell hyperactivation in Sjögren’s syndrome via fatty acid oxidation-dependent oxidative phosphorylation Article Snippet: Then protein extraction was carried out with RIPA lysis buffer (Beyotime, Shanghai, China). .. After SDS-PAGE separation and PVDF membrane transfer, the membrane was briefly sealed and detected overnight at 4 °C with primary antibodies targeting cell cycle regulators, including CDK2 (2546, CST, USA) and CDK4 (12790, CST, USA), oxidative phosphorylation related proteins, including COXIV (ab16056, Abcam, UK), ATP5A (ab176569, Abcam, UK), NDUFB8 (ab192878, Abcam, UK), Membrane:Article Title: Impaired hepatic BMAL1-FGF21 signaling drives adverse metabolic outcomes of ketogenic diet. Article Snippet: Aims The ketogenic diet (KD) has gained popularity for its metabolic benefits; however, its effects vary markedly across physiological and pathological conditions.. This study aimed to determine the mechanisms underlying differential metabolic responses to KD.. Materials and Methods Db/db, liver-specific fibroblast growth factor 21 (FGF21) knockdown mice, and liverspecific brain and muscle aryl hydrocarbon receptor nuclear translocator-like 1 (BMAL1) knockout mice were treated with isocaloric KD for 8 weeks. Article Title: Citrulline Modulates Milk Fat Metabolism via the RTN3-FABP5 Axis in Bovine Mammary Epithelial Cells. Article Snippet: Milk fat critically determines the nutritional value, flavor, and processing characteristics of dairy products.. Citrulline, a nonproteinogenic amino acid enriched in cucurbitaceous fruits, has been implicated in lipid metabolism and metabolic health.. However, its function in milk fat synthesis within bovine mammary epithelial cells (BMECs) and the associated molecular mechanisms remain undefined. Article Title: FASN-mediated metabolic reprogramming drives CD4 + T cell hyperactivation in Sjögren’s syndrome via fatty acid oxidation-dependent oxidative phosphorylation Article Snippet: Then protein extraction was carried out with RIPA lysis buffer (Beyotime, Shanghai, China). .. After SDS-PAGE separation and PVDF membrane transfer, the membrane was briefly sealed and detected overnight at 4 °C with primary antibodies targeting cell cycle regulators, including CDK2 (2546, CST, USA) and CDK4 (12790, CST, USA), oxidative phosphorylation related proteins, including COXIV (ab16056, Abcam, UK), ATP5A (ab176569, Abcam, UK), NDUFB8 (ab192878, Abcam, UK), Incubation:Article Title: Impaired hepatic BMAL1-FGF21 signaling drives adverse metabolic outcomes of ketogenic diet. Article Snippet: Aims The ketogenic diet (KD) has gained popularity for its metabolic benefits; however, its effects vary markedly across physiological and pathological conditions.. This study aimed to determine the mechanisms underlying differential metabolic responses to KD.. Materials and Methods Db/db, liver-specific fibroblast growth factor 21 (FGF21) knockdown mice, and liverspecific brain and muscle aryl hydrocarbon receptor nuclear translocator-like 1 (BMAL1) knockout mice were treated with isocaloric KD for 8 weeks. Article Title: LINC01357 reprograms fatty acid metabolism to facilitate the progression of triple-negative breast cancer by activating the MYH9-mediated Notch pathway Article Snippet: .. Membranes were incubated at 4 °C 215 overnight with the following primary antibodies: PCNA (60097-1-Ig, Proteintech, Wuhan, 216 China), E-cadherin (60335-1-Ig, Proteintech), N-cadherin (66219-1-Ig, Proteintech), 217 Vimentin (60330-1-Ig, Proteintech), HEY1 (19929-1-Ig, Proteintech), HES5 (22666-1-218 AP, Proteintech), Notch1 (10062-2-AP, Proteintech), ACC1 (21923-1-AP, Proteintech), 219 CD36 (18836-1-AP, Proteintech), CPT1A (15184-1-AP, Proteintech), MYH9 (11128-1-220 AP, Proteintech), α-Tubulin (66031-1-Ig, Proteintech), HES1 (A11718, Abclonal), Slug 221 (WL01508, Wanleibio, Shenyang, China), Phospho-proteomics:Article Title: FASN-mediated metabolic reprogramming drives CD4 + T cell hyperactivation in Sjögren’s syndrome via fatty acid oxidation-dependent oxidative phosphorylation Article Snippet: Then protein extraction was carried out with RIPA lysis buffer (Beyotime, Shanghai, China). .. After SDS-PAGE separation and PVDF membrane transfer, the membrane was briefly sealed and detected overnight at 4 °C with primary antibodies targeting cell cycle regulators, including CDK2 (2546, CST, USA) and CDK4 (12790, CST, USA), oxidative phosphorylation related proteins, including COXIV (ab16056, Abcam, UK), ATP5A (ab176569, Abcam, UK), NDUFB8 (ab192878, Abcam, UK), Cell-Signaling:Article Title: Distinct OA:PA Ratios Generate Discrete Hepatocellular Phenotypes in HepG2 Cells. Article Snippet: Proteins were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), transferred to polyvinylidene difluoride (PVDF) membranes (Bio-Rad, Hercules, CA, USA), blocked with 5% skim milk for 1 h, and incubated with primary antibodies overnight at 4 ◦C. .. Primary antibodies (all 1: 1000): AMPKα [Cell Signaling Technology (CST, Danvers, MA, USA) #2532], BAX (CST, Cat. No. 5023), BCL-2 (CST, Cat. No. 15071), BiP (CST, Cat. No. 3177S), CHOP (CST, Cat. No. 2895S), COX-2 (Abcam, Cambridge, UK, Cat. No. ab283574), |
![Prognostic validation and functional assessment of lipid metabolism regulators, fatty acid synthase ( FASN ) and stearoyl-coenzyme A desaturase ( SCD ). (A) Kaplan–Meier survival analysis indicating the prognostic significance of high expression levels of FASN (hazard ratio [HR] = 1.41) and SCD (HR = 1.8) in patients with bladder cancer (BLCA). (B) Expression analysis across stages revealed no significant variation (ANOVA, P = 0.3). (C) Colony formation assays demonstrating significantly reduced proliferation in BLCA cell lines (J82 and 5637) treated with the FASN inhibitor (FASNi; TVB-3664) and SCD inhibitor (SCDi; A939572). (D) Migration assays confirmed significantly impaired motility upon FASN and SCD inhibition, underscoring their roles in tumor aggressiveness. * P < 0.05, ** P < 0.01, *** P < 0.001, and **** P < 0.0001.](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_6492/pmc13396492/pmc13396492__csbj.0139.fig.007.jpg)